Simultaneous determination of eight short‐chain aliphatic amines in drug substances by HPLC with diode array detection after derivatization with halonitrobenzenes

Short‐chain aliphatic amines are a class of hazardous impurities in drug substances. A simple method, involving derivatization followed by high‐performance liquid chromatography with diode array detection, has been developed for residue determination of eight aliphatic amines simultaneously in drug substances. Different halonitrobenzenes derivatization reagents were systematically compared. As a result, 1‐fluoro‐2‐nitro‐4‐(trifluoromethyl)benzene was selected since the derivatization effectively shifted the absorption wavelength to the visible region (400–450 nm), where most drug substances, impurities and even the derivatization reagent absorb very weakly. Due to the redshift effect, interference was minimized and adequately low limits of quantitation were reached (0.24–0.80 nmol/mL). Moreover, the derivatization reaction was readily carried out in dimethyl sulfoxide at room temperature for 1 h using N ,N‐diisopropylethylamine as catalyst to achieve the highest yield. Without any pre‐treatment, the derivatives were analyzed by high‐performance liquid chromatography with diode array detection. The high stability of the derivatives within 24 h at room temperature (RSD<1.04%) further facilitated the simultaneous preparation and consecutive analysis of quantities of samples. Finally, the proposed method was successfully applied for residue determination of eight aliphatic amines simultaneously in eight drug substance samples. This study could be helpful for the routine analysis and residue control of aliphatic amines in drug substances.     

不确定需求与产出供应链回购契约决策

针对市场需求的不确定性和供应商产出产品合格率的不确定性,提出供应商产出量小于销售商订购量时需再生产满足销售商的订购,以及供应商生产过量和回购的产品通过折扣市场出售,建立以供应链期望利润为目标函数,以回购单价为决策变量的供应链回购契约决策模型.通过模型的分析,证明了模型存在最优的期望利润,给出了最优回购单价满足的方程;同时,也证明了最优订购量,最优生产量和销售商最优期望利润是回购单价的增函数.最后,通过算例验证了模型的有效性.     

数量折扣契约下基于成本分担的供应链突发事件协调应对

突发事件会增加供应链成本,如何进行成本分担是决定供应链能否协调应对突发事件的重要因素.用参数分别描述市场需求剧增时增加的生产成本和市场需求剧减时发生的多余产品处理成本,在数量折扣契约基础上,研究突发事件发生后制造商的最优批发价格和零售商的最优订货量,分析其影响因素比较突发事件发生前后包括市场剧增与市场剧减两种情况下的差异,并给出了数值算例.结果表明,成本分担系数和市场需求分布及其变化都会影响最优批发价格和最优订货量,只要根据市场需求变化相应调整契约参数并合理分担由突发事件增加的成本,通过数量折扣契约供应链就能够协调应对突发事件.     

非齐次树上m重非齐次马氏链的一类强偏差定理

研究给出了非齐次树上m重非齐次马氏链的一类强偏差定理.     

基于严格α-双链对角占优矩阵的非奇H-矩阵的判定准则

研究了非奇H-矩阵的判定问题.先给出了几个判定严格α-双链对角占优矩阵的充要条件,进一步利用矩阵对角占优理论得到了判定非奇H-矩阵的一些充分条件,推广和改进了已有的相关结果,并用数值算例说明了这些判定方法的有效性.     

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A Markov observation model with dividend is defined and the interpretation of the practical significance is given. We try to use an irreducible and homogeneous discrete-time Markov chain to modulate the inter-observation times and embed a dividend strategy. In the Markov observation model with dividend, a system of liner equations for the expected discounted value of dividends until ruin time is derived. Moreover, an explicit expression is obtained and proved. Finally, some interesting properties are illustrated by numerical analysis and by comparing with the complete compound binomial model with dividend.     

可持续供应链管理实践对企业绩效的影响:基于中国的实证研究

本文基于我国172家企业的问卷调查数据,运用结构方程模型,对企业可持续供应链管理实践及其对绩效的影响进行实证分析。结果表明,企业实现内部可持续管理能够对企业管理供应商的行为有着显著的影响;同时,企业管理供应商的行为作为企业外部管理实践对企业的绩效有着显著的正向影响;在企业绩效中,环境绩效和社会绩效对经济绩效有着显著的正向影响,企业的外部管理实践能够通过环境绩效和社会绩效的提高实现最终经济绩效的明显增加。     

基于改进的GM(1,1)-Markov链组合模型广东省单位GDP能耗预测

本文以灰色系统理论的GM(1,1)模型和随机过程理论的Markov链模型为基础构建了一个动态GM(1,1)-Markov链组合预测模型。该模型同时利用了GM(1,1)模型对序列趋势因素良好的拟合能力和Markov链模型对残差序列信息的提取能力。为进一步提高该模型的预测精度,用泰勒(Taylor)近似方法和新信息优先的思想对该模型进行了改进。最后,以1991-2014年广东省单位GDP能耗数据实证了该模型的预测效果。     

碳税政策下时变需求依赖库存与价格的供应链协调模型

研究由一个供应商和一个零售组成的二级供应链系统在碳税政策下的协调问题.对于市场需求率为时变函数且依赖于当前库存水平和销售价格的情形,建立分散式和集中式供应链决策模型.比较两种模型得出供应商和零售商合作能够提高供应链的整体利润但是也会产生更多的碳排放.分别利用批发价格契约和两部收费契约协调分散式决策模型得出供应链协调的条件.最后通过数值算例验证理论结果并分析碳税单价对供应链在两部收费契约下实现协调的影响.     

Option Pricing and Hedging under a Markov Switching Lévy Process Model

In this paper,we consider a Markov switching Lévy process model in which the underlying risky assets are driven by the stochastic exponential of Markov switching Lévy process and then apply the model to option pricing and hedging.In this model,the market interest rate,the volatility of the underlying risky assets and the N-state compensator,depend on unobservable states of the economy which are modeled by a continuous-time Hidden Markov process.We use the MEMM(minimal entropy martingale measure) as the equivalent martingale measure.The option price using this model is obtained by the Fourier transform method.We obtain a closed-form solution for the hedge ratio by applying the local risk minimizing hedging.